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No effect of creatine supplementation on oxidative stress and cardiovascular parameters in spontaneously hypertensive rats
Christiano RR Alves, Igor H Murai, Pamella Ramona, Humberto Nicastro, Luiz RG Bechara, Antonio H Lancha, Patrícia C Brum, Maria C Irigoyen, Bruno Gualano
Journal of the International Society of Sports Nutrition , 2012, DOI: 10.1186/1550-2783-9-13
Abstract: Lipid hydroperoxidation, one important oxidative stress marker, remained unchanged in the coronary artery (Cr: 12.6 ± 1.5 vs. Pl: 12.2 ± 1.7 nmol·mg-1; p = 0.87), heart (Cr: 11.5 ± 1.8 vs. Pl: 14.6 ± 1.1 nmol·mg-1; p = 0.15), plasma (Cr: 67.7 ± 9.1 vs. Pl: 56.0 ± 3.2 nmol·mg-1; p = 0.19), plantaris (Cr: 10.0 ± 0.8 vs. Pl: 9.0 ± 0.8 nmol·mg-1; p = 0.40), and EDL muscle (Cr: 14.9 ± 1.4 vs. Pl: 17.2 ± 1.5 nmol·mg-1; p = 0.30). Additionally, Cr supplementation affected neither arterial blood pressure nor heart structure in SHR (p > 0.05).Using a well-known experimental model of systemic arterial hypertension, this study did not confirm the possible therapeutic effects of Cr supplementation on oxidative stress and cardiovascular dysfunction associated with arterial hypertension.It has been suggested that exacerbated oxidative stress and its consequent oxidative damage may be mediators involved in cardiovascular diseases, such as systemic arterial hypertension [1]. Supporting this notion, a reduction in antioxidant bioavailability along with increased oxidative stress has been reported in both experimental and human hypertension [2].Creatine (Cr) supplementation has emerged as a promising adjunct therapy in several pathological conditions [3], including cardiovascular diseases [4,5]. Interestingly, a growing body of experimental and clinical literature has suggested that Cr may exert protective effect in diseases where exacerbated oxidative stress plays a detrimental role (e.g., Huntington's disease) [6-8]. In fact, in vitro experiments have revealed that Cr may possess antioxidant properties by acting as a scavenger of free radicals, such as superoxide anions and peroxynitrite [8,9]. For instance, Cr pre-loading was found to be cytoprotective in different cell cultures with oxidative stressors (i.e., H2O2, tBOOH and peroxynitrite) [10]. Moreover, Cr may also "indirectly" attenuate the formation of reactive oxygen species trough the coupling of Cr with ATP into the mitoch
Landau and Kolmogoroff type polynomial inequalities
Alves Claudia RR,Dimitrov Dimitar K
Journal of Inequalities and Applications , 1999,
Abstract: Let be integers. Denote by the norm . For various positive values of and we establish Kolmogoroff type inequalities with certain constants , which hold for every ( denotes the space of real algebraic polynomials of degree not exceeding ). For the particular case and , we provide a complete characterisation of the positive constants and , for which the corresponding Landau type polynomial inequalities hold. In each case we determine the corresponding extremal polynomials for which equal- ities are attained.
Josip Vajs
Rr.
- , 1960,
Abstract: Hr？ak ID: 1376
Implantando células de manufatura em uma empresa com fabrica？？o sob encomenda
Gon？alves Filho, Eduardo Vila;Christiano, Antonio Carlos;
Gest？o & Produ？？o , 1994, DOI: 10.1590/S0104-530X1994000100003
Abstract: this paper deals with design and implementation of manufacturing cells in a company producing capital goods. a classification and coding system is the tool adopted for cell design. several cells were formed and implemented. they are detailed and described along with the achieved results.
Modelos matemáticos para a rela？？o entre composi？？o química, microestrutura e propriedades mecanicas de ligas de alumínio fundidas hipoeutéticas e eutéticas
Corradi, Christiano Alves de Lima;Moita, Gray Farias;Biazi, Elenice;
Rem: Revista Escola de Minas , 2010, DOI: 10.1590/S0370-44672010000300010
Abstract: for the satisfactory accomplishment of any mechanical project, it is essential to know the characteristics of the materials that will be applied in the manufacturing process, in such a way that the resulting tension should not cause failure. the mechanical properties of the materials are established by the use of experiments or laboratory tests, carefully programmed, that reproduce, as accurately as possible, the real working conditions. however, these mechanical tests are destructive. the destructive characteristic of the experiments can be a problem when the parts that need to be tested cannot be damaged. another complexity is the determination of mechanical properties in specifi c points of the assembly, which is justifi ed mainly in foundry pieces where the cooling conditions, the microssegregations and the occurrence of defects are distributed in a heterogeneous way along the part. moreover, since the determination of the chemical composition and the microstructure is performed using non-destructive tests, they should be able to substitute the mechanical experiments, if a relationship between them could be established. this work presents mathematical models generated through statistical techniques of multiple linear regression, for the determination of the mechanical properties of hypoeutectic and eutectic aluminium foundry alloys using no destructive analyses, microstructure and chemical composition.
A importancia do índice AST/ALT no diagnóstico da esteatohepatite n？o-alcoólica
ZAMIN Jr., Idilio;MATTOS, Angelo Alves de;PERIN, Christiano;RAMOS, Gabriel Zatti;
Arquivos de Gastroenterologia , 2002, DOI: 10.1590/S0004-28032002000100005
Abstract: background/aims - there is a histologic similarity between nonalcoholic steatohepatitis and alcoholic liver disease and in some cases differential diagnosis may be difficult, since some patients do not report abusive alcohol consumption. objective - evaluating the usefulness of setting the rate ast/alt for the differential diagnosis of nonalcoholic steatohepatitis and alcoholic liver disease. patients and methods - twenty nine obese patients with nonalcoholic steatohepatitis were compared with 28 patients with alcoholic liver disease. the diagnosis of nonalcoholic steatohepatitis was made after exclusion of other causes of liver disease and by histologic findings of, at least, macrovesicular steatosis and hepatocelular necrosis. results - in patients with nonalcoholic steatohepatitis the medium ast value was 52,3 ± 21,2 u/l and alt of 90,1 ± 37,9 u/l, being the ast/alt rate lower than 1 in all patients. in patients with alcoholic liver disease the medium ast value was 140 ± 82,5 u/l and alt was 50,6 ± 40,3 u/l. the rate was higher than 1 in all cases and higher than 2 in 24 (85,7%), being statistically significant when compared with patients with nonalcoholic steatohepatitis. conclusion - the ast/alt rate seems to be useful in the differential diagnosis of liver diseases, while lower than 1 is highly suggestive of nonalcoholic steatohepatitis.
Os fungos anemófilos e sensibiliza？？o em indivíduos atópicos em Porto Alegre, RS
Mezzari, Adelina;Perin, Christiano;Santos Júnior, Sidnei Alves;Bernd, Luiz Antonio Guerra;Di Gesu, Giovani;
Revista da Associa？？o Médica Brasileira , 2003, DOI: 10.1590/S0104-42302003000300030
Abstract: objective: to identify and quantify the fungal spores in the atmospheric air of porto alegre and to assess sensitization to these allergens in atopic individuals suffering from rhinitis and asthma. methods: a total of 52 samples were obtained using a rotorod sampler？ from april 2000 through march 20001. allergy skin tests with anemophilous fungus allergens as well as fluorimmunoenzymatic tests were performed in 39 atopic individuals with rhinitis and asthma in order to detect the incidence of respiratory allergies caused by these airborne fungi. results: in the 3773 fungal spores detected in this study, there was a prevalence of ascosporos (50.49%), cladosporium (17.86%), aspergillus/penicillium (15.03%), basidiosporos (3.84%), rusts (3.82%), and helminthosporium (2.49%), as well as a lesser frequency of botrytis (1.22%), alternaria (1.19%), smuts (0.90%), curvularia (0.87%), nigrospora (0.61%), and fusarium (0.08%). sixty spores (1.59%) detected here could not be identified by the systematic key used. among the atopic individuals tested, 15.38% were found to be sensitized by these anemophilous fungi allergens. conclusions: the occurrence of a great number of fungal spores emphasizes the importance of studying anemophilous fungi locally, since they are responsible for 15.38% of allergic sensitization in atopic individuals with asthma and rhinitis.
Airborne fungi in the city of Porto Alegre, Rio Grande do Sul, Brazil
MEZZARI, Adelina;PERIN, Christiano;SANTOS JúNIOR, Sidnei Alves;BERND, Luiz Antonio Guerra;
Revista do Instituto de Medicina Tropical de S？o Paulo , 2002, DOI: 10.1590/S0036-46652002000500007
Abstract: knowledge of anemophilous fungi in a given city or region is important for the ecological diagnosis and specific treatment of allergic manifestations induced by inhaled allergens. in order to diagnose the presence of anemophilous fungi, several qualitative and quantitative techniques are used depending on the study place. this study of fungal air spores was performed with a rotorod sampler？, an equipment which samples the air through a plastic rod attached to an electric engine that makes it spin fast enough to collect the particles in the air. the samples were collected once a week during 24 hours using the standard cycle of the manufacturers. a total of 52 samples were obtained from april 2000 through march 2001. the results revealed prevalence of ascosporos (50.49%), cladosporium (17.86%), aspergillus/penicillium (15.03%), basidiosporos (3.84%), rusts (3.82%), and helminthosporium (2.49%), and a lesser frequency of botrytis (1.22%), alternaria (1.19%), smuts (0.90%), curvularia (0.87%), nigrospora (0.61%), and fusarium (0.08%). also, 1.59% of the spores detected here could not be identified by the systematic key used. more fungal spores were observed during the summer than during the autumn.
Os fungos anemófilos e sensibiliza o em indivíduos atópicos em Porto Alegre, RS
Mezzari Adelina,Perin Christiano,Santos Júnior Sidnei Alves,Bernd Luiz Antonio Guerra
Revista da Associa？？o Médica Brasileira , 2003,
Abstract: OBJETIVOS: Identificar e caracterizar a freqüência e a concentra o de esporos de fungos anemófilos em Porto Alegre. Determinar a prevalência de sensibiliza o a estes fungos em indivíduos atópicos. MéTODOS: Em 52 amostras colhidas no equipamento Rotorod Sampler , foram quantificados 3773 esporos de fungos no período de um ano (abril de 2000 a mar o de 2001). Em 39 pacientes atópicos com rinite e ou asma foram realizados testes cutaneos com alérgenos de fungos anemófilos e o teste fluorimunoenzimático para verificar a incidência de manifesta es alérgicas provocadas por tais fungos. RESULTADOS: Em 3773 esporos de fungos encontrados foram identificados 674 (17,86%) de Cladosporium sp, 567 (15,03%) do grupo Aspergillus/Penicillium, 144 (3,82%) de rusts, 94 (2,49%) de Helminthosporium sp, 46 (1,22%) de Botrytis sp, 45 (1,19%) de Alternaria sp, 34 (0,90%) de smuts, 33 (0,87%) de Curvularia sp, 23 (0,61%) de Nigrospora sp e 3 (0,08%) de Fusarium sp. Também foram encontrados 1905 (50,49%) de ascosporos e 145 (3,84%) de basidiosporos. N o foram possíveis de serem identificados 60 (1,59%) dos esporos observados. Nos 39 testes cutaneos e sorológicos realizados, resultaram em 15,38% de indivíduos atópicos sensibilizados por alérgenos de fungos em Porto Alegre. CONCLUS ES: A ocorrência de grande número de esporos de fungos no ar em nossa cidade enfatiza a importancia deste estudo sobre os fungos anemófilos, sendo eles responsáveis por 15,38% das sensibiliza es alérgicas em indivíduos atópicos com manifesta es de asma e ou rinite.
Airborne fungi in the city of Porto Alegre, Rio Grande do Sul, Brazil
MEZZARI Adelina,PERIN Christiano,SANTOS JúNIOR Sidnei Alves,BERND Luiz Antonio Guerra
Revista do Instituto de Medicina Tropical de S？o Paulo , 2002,
Abstract: Knowledge of anemophilous fungi in a given city or region is important for the ecological diagnosis and specific treatment of allergic manifestations induced by inhaled allergens. In order to diagnose the presence of anemophilous fungi, several qualitative and quantitative techniques are used depending on the study place. This study of fungal air spores was performed with a Rotorod Sampler , an equipment which samples the air through a plastic rod attached to an electric engine that makes it spin fast enough to collect the particles in the air. The samples were collected once a week during 24 hours using the standard cycle of the manufacturers. A total of 52 samples were obtained from April 2000 through March 2001. The results revealed prevalence of ascosporos (50.49%), Cladosporium (17.86%), Aspergillus/Penicillium (15.03%), basidiosporos (3.84%), rusts (3.82%), and Helminthosporium (2.49%), and a lesser frequency of Botrytis (1.22%), Alternaria (1.19%), smuts (0.90%), Curvularia (0.87%), Nigrospora (0.61%), and Fusarium (0.08%). Also, 1.59% of the spores detected here could not be identified by the systematic key used. More fungal spores were observed during the summer than during the autumn.
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